What is Methylation and MTHFR?

Methylation is the passing of a chemical called a methyl group (a carbon atom linked to three hydrogen atoms) from one molecule to another. It is most easily understood by thinking of methylation as a domino series in your body.

The Methylation cycle is responsible for the function of:

The MTHFR gene provides instructions for making an enzyme called methylenetetrahydrofolate reductase. This enzyme plays a role in processing amino acids, the building blocks of proteins. Methylenetetrahydrofolate reductase is important for a chemical reaction involving forms of the B-vitamin folate (also called folic acid or vitamin B9). Specifically, this enzyme converts 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate.


A single-nucleotide polymorphism (SNP, pronounced snip; plural snips) is a DNA sequence variation occurring when a single nucleotide — A, T, C or G — in the genome (or other shared sequence) differs between members of a biological species or paired chromosomes in a human(1).

Functions of Methylation:

  • Epigenetics (Turns Genes On/Off)
  • Protects and Stabilizes DNA
  • Activates + Deactivates Stress Hormones
  • Activates Serotonin, Melatonin and Dopamine
  • Energy (ATP) Production
  • Detoxification
  • Growth + Healing
  • Autonomic Nervous System (ANS)
  • Immune System

Methylation signs and Symptoms:

  • Chronic Fatigue
  • Sleep Disorders
  • Inability to Adapt to Stress
  • Toxic Encephalitis
  • Genetic Disorders
  • Hormone Dysregulation
  • Cancer

What causes your Methylation to fail?

That is a fantastic question, there are many variables involved in a faulty Methlyation cycle, such as:

  • Genetics
  • Diet
  • Over consumption of Sugar
  • Deficiency of B12=Folate
  • Malabsorption
  • Toxins
  • Stress

I hope you guys enjoyed todays post about Methylation and MTHFR.

 View Ameer Rosic’s Primal Docs Profile

About Ameer Rosic, RHN

My background includes education as a Registered Holistic Nutritionist, Functional Diagnostic Practitioner and Functional Medicine Practitioner. I’m also a black belt in Shotokan Karate and kettlebell training enthusiast, which led me to win the 2012 Canadian Kettlebell Biathlon Championship. I’ve also written a book on kettlebell exercise training and kettlebell routines, called The Kettlebell Advantage and currently writing my second book Diagnostic Testing and Functional Medicine.

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This article is for informational purposes only, and is educational in nature. Statements made here have not been evaluated by the FDA. This article is not intended to diagnose, treat, cure or prevent any disease. Please discuss with your own, qualified health care provider before adding in supplements or making any changes in your diet.