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What is Methylation and MTHFR?

Methylation is the passing of a chemical called a methyl group (a carbon atom linked to three hydrogen atoms) from one molecule to another. It is most easily understood by thinking of methylation as a domino series in your body.

The Methylation cycle is responsible for the function of:

The MTHFR gene provides instructions for making an enzyme called methylenetetrahydrofolate reductase. This enzyme plays a role in processing amino acids, the building blocks of proteins. Methylenetetrahydrofolate reductase is important for a chemical reaction involving forms of the B-vitamin folate (also called folic acid or vitamin B9). Specifically, this enzyme converts 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate.


A single-nucleotide polymorphism (SNP, pronounced snip; plural snips) is a DNA sequence variation occurring when a single nucleotide — A, T, C or G — in the genome (or other shared sequence) differs between members of a biological species or paired chromosomes in a human(1).

Functions of Methylation:

  • Epigenetics (Turns Genes On/Off)
  • Protects and Stabilizes DNA
  • Activates + Deactivates Stress Hormones
  • Activates Serotonin, Melatonin and Dopamine
  • Energy (ATP) Production
  • Detoxification
  • Growth + Healing
  • Autonomic Nervous System (ANS)
  • Immune System

Methylation signs and Symptoms:

  • Chronic Fatigue
  • Sleep Disorders
  • Inability to Adapt to Stress
  • Toxic Encephalitis
  • Genetic Disorders
  • Hormone Dysregulation
  • Cancer

What causes your Methylation to fail?

That is a fantastic question, there are many variables involved in a faulty Methlyation cycle, such as:

  • Genetics
  • Diet
  • Over consumption of Sugar
  • Deficiency of B12=Folate
  • Malabsorption
  • Toxins
  • Stress

I hope you guys enjoyed todays post about Methylation and MTHFR.

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