In Monday’s video, we discussed a fantastic study demonstrating the effects that selenium and CoQ10 supplementation have on cardiovascular disease. The results indicated a significant decrease in death from CVD when supplementing with selenium and CoQ10. Discover if adding Selenium and CoQ10 might be helpful for you.
If you need help with heart health, click here.
In Monday’s video, we discussed a fantastic study demonstrating the effects that selenium and CoQ10 supplementation have on cardiovascular disease. The results indicated a significant decrease in death from cardiovascular disease when supplementing with selenium and CoQ10.
“A 10-year evaluation of CV mortality in an elderly Swedish healthy population that was given dietary supplementation with selenium and coenzyme Q10 over a period of four years, indicated a reduced risk of cardiovascular mortality by 50% and a post-intervention persistency of protection against CV mortality.”
Previous studies have shown that there is a complex relationship between coenzyme Q10 and selenium, in which selenium is needed in order to facilitate reduction of CoQ10 to ubiquinol, the active form.
The trace element selenium is a powerful antioxidant that is essential for all living cells. It is mostly found as selenoproteins in the body, including glutathione peroxidases, thioredoxin reductase, and selenoprotein P, which protect against oxidative stress.
Optimal levels of selenium are needed for the maintenance of normal cell function.
CoQ10 is naturally produced in the body and is a key element in energy production and antioxidant protection. Yet most people have insufficient amounts of CoQ10.
An adequate amount of CoQ10 is needed for optimal synthesis of selenocysteine-containing enzymes. Also, a deficiency of selenium may influence the ability to get adequate concentrations of active CoQ10 in cellular compartments.
CoQ10 has been shown to have effects on the endothelial function. We also know that CoQ10 is a powerful antioxidant, mainly against lipid peroxidation.
Both selenium and CoQ10 are needed to combat oxidative stress, a condition that may accompany any inflammation, and affect any human cell throughout its lifetime.
This double-blind, placebo-controlled study involved 443 healthy, elderly individuals ages 70 to 88. They were given selenium and CoQ10 or placebo for four years. The supplement dosing in the active group was 200mg CoQ10 and 200mcg selenium per day. The selenium supplementation was in the form of organic selenium yeast tablets.
Not only were the initial results very positive, but those four years of supplementation significantly decreased death for 10 years after stopping supplementation.
The great thing about this study is that it evaluated outcomes, which is the most important. We are seeing a positive benefit on outcomes, not just a change in a risk marker. Here we see that this form of supplementation causes an outcome of reduced death. This study shows a positive impact on the end result, which is very encouraging.
The main results were significantly reduced cardiovascular mortality, improved cardiac function as evaluated on echocardiography, and a reduced increase of the N-terminal fragment of proBNP (NT-proBNP), a cardiac peptide biomarker. The study also reported increased health-related quality of life in those with active treatment of selenium and CoQ10.
The reduced mortality could be seen to persist during the 10-year period. Subgroup analysis showed positive effects in both genders. An equally positive risk reduction could be seen in those with ischemic heart disease.
Things to consider:
- This study was done with an elderly population. We don’t know if the results would be the same with a younger population. Elderly patients generally don’t absorb their nutrients from food as well, so they may tend to do better with supplemental forms of nutrients. Therefore, the effects could possibly be stronger for the elderly.
- This study was performed in Sweden, and it’s known that the selenium content in the soil is low in Europe compared to the US. Therefore, the average intake of selenium from food in Europe is significantly less than the average intake in the US.
Regardless, this is still a great supplemental option to consider if you’re younger and you’re trying to prevent heart disease.
In addition to supplementation, you can incorporate foods that contain selenium and CoQ10, although it can be difficult to get enough of these antioxidants from food alone.
Foods high in selenium include:
- Brazil nuts
- Yellowfin tuna
- Cooked halibut
- Canned sardines
- Grassfed beef
- Beef liver
Foods containing CoQ10 include:
- Dark, leafy greens
If you’re considering supplementation, below is our recommended protocol.
Disclaimer: This content is for informational purposes only. You should consult with your doctor before using any of these products.
If you need help with heart health, click here
What do you think? I would like to hear your thoughts or experience with this.
The post These Two Antioxidants May Reduce Your Risk of Death from Heart Disease appeared first on Dr. Michael Ruscio.