Migraine Headaches & MTHFR


If you or your family member sufferers from migraines it is important to look at the triggers and links for optimal treatment.

A headache can come on at any time and for a number of reasons. However, People who suffer from migraines experience much more complicated symptoms that are often debilitating. Aside from pain, migraines often bring on nausea, vomiting, visual, light and sound sensitivity. Migraines can start as early as 5 years old and can be triggered by foods, stress, hormone changes, chemicals and the environment.  A number of studies have implicated genes such as MTHFR in migraine headaches.

MTHFR also affects the characteristics of migraine symptoms. One study found that having 2 copies of c677T was associated with migraine with aura and one-sided headache, yet, one copy of c677T was associated with “physical activity and stress as a migraine trigger.” The researchers also found there is tremendous difference in symptoms between men and women. Males with 2 copies of c677T, for example, were more prone to bilateral headaches while the females with one copy of c677T experienced symptoms of nausea and odor aversion more frequently. These studies conclude that there is an overwhelmingly higher incidence of migraine in patients with a MTHFR mutation than without one.

Other gene SNPs associated with migraine headaches includes MTHFR, KCNK, TRPV, and HCRTR. Yet, MTHFR C677T is the most studied in relation to migraines. When an individual is diagnosed with a vascular type of migraine it is highly correlates with c677T and elevated homocysteine levels. Elevated homocysteine, can inflame the inner lining of the nerves and blood vessels, which can contribute to migraines.  Another other concern with migraine and MTHFR is the increased incidence of stroke and cardiovascular compilations. Carrying a MTHFR mutation can also predispose the brain to being more sensitive to changes in weather, neurochemical production and have impaired detox capability, all of these can make a brain more sensitive and prone to migraine.

Some easy tips to treat migraine include:

  • Avoid any food triggers such as preservatives, chemicals, dyes, aged foods (with mold or fungus), gluten and dairy proteins; all of these can be neurotoxic to the brain. The diet should be followed for 3 months before any result is evaluated.
  • Get tested for MTHFR and manage the mutation properly with a qualified provider, individuals with MTHFR OR Migraine are not candidates for hormonal contraception or treatment and should avoid this trigger.
  • Individuals with MTHFR may have elevated homocysteine. Elevated homocysteine is also found in individuals with migraine. One study proved lowering homocysteine levels through vitamin supplementation reduced migraine disability. Speak to your provider about testing and management.
  • Check your blood sugar, highs and lows with blood sugar can trigger a migraine, keep your eating consistent and check out my book for more recipes.
  • Make sure sleep is adequate, the body needs rest and relaxation; avoid TV, blue lights or screens in the bedroom.
  • Consider chiropractic the research is overwhelming in success of treatment of migraine.
  • Detox the house, be sure there aren’t chemical triggers or chemicals triggering the migraine in your home. Consider natural cleaners, natural products and testing on water and paint for toxicity or chemicals.
  • Fix the gut. Using quality probiotic and fish oil can be very helpful in reducing triggers, inflammation and increasing oxygen to the brain. Ask your provider about the highest quality supplements and be sure they come from a reputable source or they could do the opposite in your body.
  • For children, allow them to be a part of their healing, talk to them about health and nutrition, and model healthy choices for them, explain the disease process and how to reduce the incidence.

Remember healing takes time, migraine can feel very isolating, get help, get support and get better!!

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